Far upstream element-binding protein 1

FUBP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1J4W, 2KXH, 4LIJ
Identifiers
Aliases	FUBP1, FBP, FUBP, hDH V, far upstream element binding protein 1
External IDs	OMIM: 603444; MGI: 1196294; HomoloGene: 48253; GeneCards: FUBP1; OMA:FUBP1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	77,979,110 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	151,942,463 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; Achilles tendon; ; left ovary; ; right uterine tube; ; right ovary; ; body of uterus; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; canal of the cervix;
	Top expressed in
	genital tubercle; ; tail of embryo; ; ventricular zone; ; maxillary prominence; ; mandibular prominence; ; epiblast; ; somite; ; abdominal wall; ; ganglionic eminence; ; Rostral migratory stream;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; nucleic acid binding; single-stranded DNA binding; DNA-binding transcription factor activity; DNA binding; RNA binding;
Cellular component	nucleus; nucleoplasm;
Biological process	positive regulation of gene expression; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	8880
	51886
	ENSG00000162613
	ENSMUSG00000028034
	Q96AE4
	Q91WJ8
	NM_001303433; NM_003902; NM_001376055; NM_001376056; NM_001376057
NM_057172; NM_001355366; NM_001355367; NM_001355368; NM_001355369;
	NM_001355370; NM_001355371; NM_001355372; NM_001355373; NM_001355374
	NP_001290362; NP_003893; NP_001362984; NP_001362985; NP_001362986
NP_476513; NP_001342295; NP_001342296; NP_001342297; NP_001342298;
	NP_001342299; NP_001342300; NP_001342301; NP_001342302; NP_001342303
	Wikidata
View/Edit Human	View/Edit Mouse

Far upstream element-binding protein 1 is a protein that in humans is encoded by the FUBP1 gene.

This gene encodes a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase.