RNA-binding protein FUS

FUS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LA6, 2LCW, 4FDD, 4FQ3
Identifiers
Aliases	FUS, ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS, FUS RNA binding protein, altFUS
External IDs	OMIM: 137070; MGI: 1353633; GeneCards: FUS; OMA:FUS - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	31,191,605 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	127,584,873 bp
RNA expression pattern
	Top expressed in
	right testis; ; ventricular zone; ; right hemisphere of cerebellum; ; left testis; ; ganglionic eminence; ; right uterine tube; ; right ovary; ; left ovary; ; right lobe of thyroid gland; ; body of uterus;
	Top expressed in
	somite; ; ventricular zone; ; neural layer of retina; ; otic placode; ; mandibular prominence; ; Gonadal ridge; ; molar; ; abdominal wall; ; migratory enteric neural crest cell; ; saccule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription coactivator activity; metal ion binding; retinoid X receptor binding; thyroid hormone receptor binding; myosin V binding; protein binding; identical protein binding; nucleic acid binding; ionotropic glutamate receptor binding; estrogen receptor binding; RNA binding; chromatin binding;
Cellular component	cytoplasm; polysome; perikaryon; dendritic spine; nucleoplasm; soma; dendrite; dendritic spine head; perinuclear region of cytoplasm; nucleus;
Biological process	cellular response to calcium ion; mRNA splicing, via spliceosome; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; RNA splicing; regulation of RNA splicing; protein homooligomerization; positive regulation of nucleic acid-templated transcription; positive regulation of double-strand break repair via homologous recombination;
	Sources:Amigo / QuickGO
Orthologs
	2521
	233908
	ENSG00000089280
	ENSMUSG00000030795
	P35637
	P56959
	NM_001010850; NM_001170634; NM_001170937; NM_004960
	NM_139149; NM_001347649
	NP_001164105; NP_001164408; NP_004951
	NP_001334578; NP_631888
	Wikidata
View/Edit Human	View/Edit Mouse

RNA-binding protein fused in sarcoma/translocated in liposarcoma (FUS/TLS), also known as heterogeneous nuclear ribonucleoprotein P2 is a protein that in humans is encoded by the FUS gene.