FUT2

FUT2
Identifiers
Aliases	FUT2, B12QTL1, SE, SEC2, Se2, sej, fucosyltransferase 2
External IDs	OMIM: 182100; MGI: 109374; HomoloGene: 10325; GeneCards: FUT2; OMA:FUT2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,705,951 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,315,818 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; nasal epithelium; ; minor salivary glands; ; pancreatic ductal cell; ; mucosa of transverse colon; ; buccal mucosa cell; ; duodenum; ; oral cavity; ; rectum; ; palpebral conjunctiva;
	Top expressed in
	lip; ; left colon; ; epithelium of stomach; ; skin of external ear; ; seminal vesicula; ; duodenum; ; esophagus; ; migratory enteric neural crest cell; ; skin of back; ; lobe of prostate;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; galactoside 2-alpha-L-fucosyltransferase activity; glycosyltransferase activity; fucosyltransferase activity;
Cellular component	integral component of membrane; Golgi cisterna membrane; Golgi apparatus; extracellular exosome; membrane;
Biological process	protein glycosylation; L-fucose catabolic process; fucosylation; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	2524
	14344
	ENSG00000176920
	ENSMUSG00000055978
	Q10981
	Q9JL27
	NM_001097638; NM_000511
	NM_001271993; NM_018876
	NP_000502; NP_001091107
	NP_001258922; NP_061364
	Wikidata
View/Edit Human	View/Edit Mouse

Galactoside 2-alpha-L-fucosyltransferase 2 is an enzyme that in humans is encoded by the FUT2 (fucosyltransferase 2) gene.

FUT2 is a key enzyme that catalyzes the transfer of L-fucose from guanosine diphosphate-beta-L-fucose to the terminal galactose on both O- and N-linked glycans of cell surface glycoproteins and glycolipids. This enzymatic activity is essential for the synthesis of the H antigen, a precursor required for the formation of ABO blood group antigens, and determines "secretor status"—the presence of blood group antigens in bodily fluids such as saliva. Beyond its role in blood group antigen synthesis, FUT2 influences cell-cell interactions, modulates the composition of the gut microbiome, and impacts susceptibility to infections and autoimmune diseases, highlighting its broad significance in human health and disease.

Approximately 20% of Caucasians are non-secretors due to the G428A (rs601338) and C571T (rs492602?) nonsense mutations in FUT2 and therefore have strong although not absolute protection from the norovirus GII.4.\