FUT6

FUT6
Identifiers
Aliases	FUT6, FCT3A, FT1A, Fuc-TVI, FucT-VI, fucosyltransferase 6
External IDs	OMIM: 136836; HomoloGene: 34780; GeneCards: FUT6; OMA:FUT6 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	5,839,722 bp
RNA expression pattern
	Top expressed in
	mucosa of pharynx; ; olfactory bulb; ; buccal mucosa cell; ; pancreatic ductal cell; ; nasal epithelium; ; mucosa of ileum; ; amniotic fluid; ; trachea; ; oral cavity; ; mucosa of transverse colon;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; alpha-(1->3)-fucosyltransferase activity; 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity; glycosyltransferase activity; fucosyltransferase activity;
Cellular component	integral component of membrane; Golgi cisterna membrane; Golgi apparatus; extracellular exosome; membrane; Golgi membrane;
Biological process	protein glycosylation; L-fucose catabolic process; fucosylation; ceramide metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	2528
	n/a
	ENSG00000156413
	n/a
	P51993
	n/a
NM_000150; NM_001040701; NM_001369502; NM_001369504; NM_001369505;
	NM_001381955; NM_001381956; NM_001381957; NM_001381958; NM_001381959
	n/a
NP_000141; NP_001035791; NP_001356431; NP_001356433; NP_001356434;
	NP_001368884; NP_001368885; NP_001368886; NP_001368887; NP_001368888
	n/a
	Wikidata
View/Edit Human

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT6 gene.

The alpha-1,3-fucosyltransferases constitute a large family of glycosyltransferases with a high degree of homology. The enzymes of this family comprise 3 main activity patterns called myeloid, plasma, and Lewis, based on their capacity to transfer alpha-L-fucose to distinct oligosaccharide acceptors, their sensitivity to N-ethylmaleimide inhibition, their cation requirements, and their tissue-specific expression patterns. The different categories of alpha-1,3-fucosyltransferases are sequentially expressed during embryo-fetal development.[supplied by OMIM]