FXR1

FXR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CPQ, 3KUF, 3O8V
Identifiers
Aliases	FXR1, FXR1P, FMR1 autosomal homolog 1, MYORIBF, MYOPMIL
External IDs	OMIM: 600819; MGI: 104860; HomoloGene: 3573; GeneCards: FXR1; OMA:FXR1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	180,982,753 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	34,124,471 bp
RNA expression pattern
	Top expressed in
	sperm; ; muscle of thigh; ; gastrocnemius muscle; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; triceps brachii muscle; ; glutes; ; ventricular zone; ; left testis; ; right testis;
	Top expressed in
	seminiferous tubule; ; spermatid; ; temporal muscle; ; muscle of thigh; ; ankle; ; spermatocyte; ; sternocleidomastoid muscle; ; tail of embryo; ; triceps brachii muscle; ; digastric muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; G-quadruplex RNA binding; mRNA 3'-UTR binding; protein binding; protein heterodimerization activity; nucleic acid binding; mRNA binding; RNA strand annealing activity; RNA binding; translation regulator activity;
Cellular component	membrane; ribonucleoprotein granule; dendritic spine; axon; dendrite; nucleolus; perinuclear region of cytoplasm; costamere; nucleus; cytosol; cytoplasm; polysome; postsynaptic density; cytoplasmic ribonucleoprotein granule; soma; postsynapse; glutamatergic synapse;
Biological process	cell differentiation; muscle organ development; multicellular organism development; apoptotic process; positive regulation of gene silencing by miRNA; negative regulation of translation; regulation of translation; regulation of mRNA stability; positive regulation of translation;
	Sources:Amigo / QuickGO
Orthologs
	8087
	14359
	ENSG00000114416
	ENSMUSG00000027680
	P51114
	Q61584
	NM_001013438; NM_001013439; NM_005087; NM_001363882
	NM_001113188; NM_001113189; NM_008053
	NP_001013456; NP_001013457; NP_005078; NP_001350811
	NP_001106659; NP_001106660; NP_032079
	Wikidata
View/Edit Human	View/Edit Mouse

Fragile X mental retardation syndrome-related protein 1 is a protein that in humans is encoded by the FXR1 gene.

The protein encoded by this gene is an RNA binding protein that interacts with the functionally similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.