FYVE domain
| FYVE zinc finger | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Early endosome antigen 1 (EEA1) dimer with lipids. | |||||||||
| Identifiers | |||||||||
| Symbol | FYVE | ||||||||
| Pfam | PF01363 | ||||||||
| InterPro | IPR000306 | ||||||||
| PROSITE | PDOC50178 | ||||||||
| SCOP2 | 1vfy / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 59 | ||||||||
| OPM protein | 1vfy | ||||||||
| CDD | cd00065 | ||||||||
| |||||||||
In molecular biology the FYVE zinc finger domain is named after the four cysteine-rich proteins: Fab 1 (yeast orthologue of PIKfyve), YOTB, Vac 1 (vesicle transport protein), and EEA1, in which it has been found. FYVE domains bind phosphatidylinositol 3-phosphate, in a way dependent on its metal ion coordination and basic amino acids. The FYVE domain inserts into cell membranes in a pH-dependent manner. The FYVE domain has been connected to vacuolar protein sorting and endosome function.