Frizzled-1

FZD1
Identifiers
Aliases	FZD1, frizzled class receptor 1
External IDs	OMIM: 603408; MGI: 1196625; HomoloGene: 20750; GeneCards: FZD1; OMA:FZD1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	91,271,326 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	4,808,035 bp
RNA expression pattern
	Top expressed in
	lactiferous duct; ; visceral pleura; ; tail of epididymis; ; tendon of biceps brachii; ; Epithelium of choroid plexus; ; parietal pleura; ; trigeminal ganglion; ; superficial temporal artery; ; hair follicle; ; spinal ganglia;
	Top expressed in
	gastrula; ; calvaria; ; vas deferens; ; umbilical cord; ; habenula; ; hair follicle; ; aortic valve; ; decidua; ; ascending aorta; ; endocardial cushion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	PDZ domain binding; frizzled binding; signal transducer activity; Wnt-protein binding; protein binding; Wnt-activated receptor activity; signaling receptor binding; transmembrane signaling receptor activity; G protein-coupled receptor activity;
Cellular component	Wnt signalosome; membrane; focal adhesion; plasma membrane; cell surface; integral component of membrane;
Biological process	G protein-coupled receptor signaling pathway; positive regulation of protein phosphorylation; autocrine signaling; epithelial cell differentiation; muscular septum morphogenesis; ventricular septum morphogenesis; cell-cell signaling; membranous septum morphogenesis; outflow tract morphogenesis; positive regulation of DNA-binding transcription factor activity; Wnt signaling pathway; planar cell polarity pathway involved in neural tube closure; negative regulation of BMP signaling pathway; positive regulation of transcription, DNA-templated; multicellular organism development; cell surface receptor signaling pathway; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation; canonical Wnt signaling pathway involved in osteoblast differentiation; hard palate development; neuron differentiation; canonical Wnt signaling pathway; negative regulation of transcription, DNA-templated; signal transduction; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; beta-catenin destruction complex disassembly; Wnt signaling pathway, planar cell polarity pathway; presynapse assembly; negative regulation of oxidative stress-induced neuron death; non-canonical Wnt signaling pathway; positive regulation of neuron projection development; negative regulation of canonical Wnt signaling pathway; regulation of presynapse assembly;
	Sources:Amigo / QuickGO
Orthologs
	8321
	14362
	ENSG00000157240
	ENSMUSG00000044674
	Q9UP38
	O70421
	NM_003505
	NM_021457
	NP_003496
	NP_067432
	Wikidata
View/Edit Human	View/Edit Mouse

Frizzled-1 (Fz-1) is a protein that in humans is encoded by the FZD1 gene.