Frizzled-2

FZD2
Identifiers
Aliases	FZD2, Fz2, fz-2, fzE2, hFz2, frizzled class receptor 2, OMOD2
External IDs	OMIM: 600667; MGI: 1888513; HomoloGene: 20377; GeneCards: FZD2; OMA:FZD2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	44,561,262 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	102,498,884 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; embryo; ; spinal ganglia; ; ganglionic eminence; ; stromal cell of endometrium; ; trigeminal ganglion; ; glomerulus; ; metanephric glomerulus; ; retinal pigment epithelium; ; right coronary artery;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; ureter; ; medullary collecting duct; ; mandibular prominence; ; vas deferens; ; fossa; ; maxillary prominence; ; condyle; ; ascending aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	PDZ domain binding; signal transducer activity; protein binding; transmembrane signaling receptor activity; G protein-coupled receptor activity; Wnt-protein binding; Wnt-activated receptor activity;
Cellular component	cytoplasm; clathrin-coated endocytic vesicle membrane; membrane; focal adhesion; plasma membrane; integral component of membrane;
Biological process	G protein-coupled receptor signaling pathway; epithelial cell differentiation; muscular septum morphogenesis; ventricular septum morphogenesis; cell-cell signaling; membranous septum morphogenesis; outflow tract morphogenesis; positive regulation of DNA-binding transcription factor activity; Wnt signaling pathway; planar cell polarity pathway involved in neural tube closure; positive regulation of transcription, DNA-templated; multicellular organism development; sensory perception of smell; cell surface receptor signaling pathway; inner ear receptor cell development; hard palate development; cochlea morphogenesis; neuron differentiation; canonical Wnt signaling pathway; signal transduction; beta-catenin destruction complex disassembly; Wnt signaling pathway, calcium modulating pathway; Wnt signaling pathway, planar cell polarity pathway; non-canonical Wnt signaling pathway; positive regulation of G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2535
	57265
	ENSG00000180340
	ENSMUSG00000050288
	Q14332
	Q9JIP6
	NM_001466
	NM_020510
	NP_001457
	NP_065256
	Wikidata
View/Edit Human	View/Edit Mouse

Frizzled-2 (Fz-2) is a protein that in humans is encoded by the FZD2 gene.

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary.