Frizzled-3

FZD3
Identifiers
Aliases	FZD3, Fz-3, frizzled class receptor 3
External IDs	OMIM: 606143; MGI: 108476; HomoloGene: 23004; GeneCards: FZD3; OMA:FZD3 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	28,574,267 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	65,499,912 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; secondary oocyte; ; corpus epididymis; ; middle temporal gyrus; ; endothelial cell; ; entorhinal cortex; ; parietal lobe; ; postcentral gyrus; ; cerebellar vermis; ; buccal mucosa cell;
	Top expressed in
	medial ganglionic eminence; ; Rostral migratory stream; ; anterior amygdaloid area; ; olfactory tubercle; ; ventromedial nucleus; ; vestibular sensory epithelium; ; trigeminal ganglion; ; substantia nigra; ; lateral septal nucleus; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	PDZ domain binding; signal transducer activity; Wnt-protein binding; protein binding; transmembrane signaling receptor activity; G protein-coupled receptor activity; Wnt-activated receptor activity;
Cellular component	cytoplasm; lateral plasma membrane; membrane; plasma membrane; apical part of cell; presynaptic active zone; cell surface; axon; filopodium tip; soma; dendrite; apical plasma membrane; integral component of membrane;
Biological process	hair follicle development; dopaminergic neuron axon guidance; positive regulation of neuroblast proliferation; sympathetic ganglion development; G protein-coupled receptor signaling pathway; negative regulation of execution phase of apoptosis; negative regulation of mitotic cell cycle, embryonic; serotonergic neuron axon guidance; establishment of planar polarity; cell proliferation in midbrain; neuron migration; Wnt signaling pathway; commissural neuron axon guidance; nervous system development; multicellular organism development; neural tube closure; cell surface receptor signaling pathway; inner ear morphogenesis; neuron differentiation; post-anal tail morphogenesis; canonical Wnt signaling pathway; midbrain morphogenesis; midbrain development; signal transduction; response to electrical stimulus; Wnt signaling pathway, calcium modulating pathway; brain development; planar cell polarity pathway involved in axon guidance; Wnt signaling pathway, planar cell polarity pathway; non-canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7976
	14365
	ENSG00000104290
	ENSMUSG00000007989
	Q9NPG1
	Q61086
	NM_017412; NM_145866
	NM_021458
	NP_059108; NP_665873
	NP_067433
	Wikidata
View/Edit Human	View/Edit Mouse

Frizzled-3 (Fz-3) is a protein that in humans is encoded by the FZD3 gene.