Frizzled-5

FZD5
Identifiers
Aliases	FZD5, C2orf31, HFZ5, frizzled class receptor 5
External IDs	OMIM: 601723; MGI: 108571; HomoloGene: 2590; GeneCards: FZD5; OMA:FZD5 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	207,769,906 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	64,776,910 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of sigmoid colon; ; lower lobe of lung; ; mucosa of ileum; ; duodenum; ; mucosa of transverse colon; ; palpebral conjunctiva; ; kidney tubule; ; visceral pleura; ; tibia;
	Top expressed in
	median eminence; ; hair follicle; ; epithelium of small intestine; ; epithelium of stomach; ; ciliary body; ; left colon; ; arcuate nucleus; ; Paneth cell; ; calvaria; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	amyloid-beta binding; signal transducer activity; Wnt-protein binding; protein binding; protein kinase binding; ubiquitin protein ligase binding; transmembrane signaling receptor activity; Wnt-activated receptor activity; G protein-coupled receptor activity;
Cellular component	clathrin-coated endocytic vesicle membrane; Golgi apparatus; early endosome membrane; membrane; bicellular tight junction; Golgi membrane; plasma membrane; cell surface; early endosome; perinuclear region of cytoplasm; integral component of membrane;
Biological process	G protein-coupled receptor signaling pathway; T cell differentiation in thymus; chorionic trophoblast cell differentiation; positive regulation of protein targeting to mitochondrion; positive regulation of JUN kinase activity; apoptotic process involved in morphogenesis; regulation of chorionic trophoblast cell proliferation; regulation of bicellular tight junction assembly; regulation of canonical Wnt signaling pathway; cellular response to molecule of bacterial origin; positive regulation of interferon-gamma production; embryonic axis specification; labyrinthine layer blood vessel development; cell maturation; Wnt signaling pathway; embryonic camera-type eye development; multicellular organism development; cell surface receptor signaling pathway; vasculature development; regulation of autophagy of mitochondrion; branching involved in labyrinthine layer morphogenesis; embryonic camera-type eye morphogenesis; post-embryonic camera-type eye development; positive regulation of T cell cytokine production; angiogenesis; neuron differentiation; Wnt signaling pathway involved in dorsal/ventral axis specification; canonical Wnt signaling pathway; synapse assembly; syncytiotrophoblast cell differentiation involved in labyrinthine layer development; anterior/posterior axis specification, embryo; Spemann organizer formation; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; signal transduction; Wnt signaling pathway, calcium modulating pathway; Wnt signaling pathway, planar cell polarity pathway; beta-catenin destruction complex disassembly;
	Sources:Amigo / QuickGO
Orthologs
	7855
	14367
	ENSG00000163251
	ENSMUSG00000045005
	Q13467
	Q9EQD0
	NM_030804; NM_003468
	NM_001033193; NM_001042659; NM_022721
	NP_003459
	NP_001036124; NP_073558
	Wikidata
View/Edit Human	View/Edit Mouse

Frizzled-5 (Fz-5) is a protein that in humans is encoded by the FZD5 gene.

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. Fz-5 is believed to be the receptor for the Wnt5A ligand.