Frizzled-6

FZD6
Identifiers
Aliases	FZD6, FZ-6, FZ6, HFZ6, NDNC10, frizzled class receptor 6, NDNC1
External IDs	OMIM: 603409; MGI: 108474; HomoloGene: 2617; GeneCards: FZD6; OMA:FZD6 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	103,332,866 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	38,901,583 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; caput epididymis; ; Epithelium of choroid plexus; ; skin of thigh; ; skin of hip; ; corpus epididymis; ; epithelium of nasopharynx; ; palpebral conjunctiva; ; secondary oocyte; ; hair follicle;
	Top expressed in
	lip; ; uterus; ; genital tubercle; ; lens; ; esophagus; ; zone of skin; ; heart; ; spermatocyte; ; urethra; ; lower respiratory tract;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; protein binding; Wnt-activated receptor activity; ubiquitin protein ligase binding; transmembrane signaling receptor activity; G protein-coupled receptor activity; Wnt-protein binding; amyloid-beta binding;
Cellular component	membrane; apical part of cell; integral component of plasma membrane; cell surface; apicolateral plasma membrane; apical plasma membrane; cytoplasmic vesicle membrane; cytoplasmic vesicle; plasma membrane; integral component of membrane;
Biological process	hair follicle development; G protein-coupled receptor signaling pathway; non-canonical Wnt signaling pathway; establishment of planar polarity; cell proliferation in midbrain; Wnt signaling pathway; negative regulation of DNA-binding transcription factor activity; platelet activation; multicellular organism development; Wnt signaling pathway, planar cell polarity pathway; embryonic nail plate morphogenesis; cell surface receptor signaling pathway; neural tube closure; inner ear morphogenesis; midbrain morphogenesis; negative regulation of canonical Wnt signaling pathway; signal transduction; midbrain development; Wnt signaling pathway, calcium modulating pathway; establishment of body hair planar orientation; canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8323
	14368
	ENSG00000164930
	ENSMUSG00000022297
	O60353
	Q61089
	NM_001164615; NM_001164616; NM_003506; NM_001317796
	NM_001162494; NM_008056
NP_001158087; NP_001158088; NP_001304725; NP_003497; NP_001158087.1;
	NP_003497.2
	NP_001155966; NP_032082
	Wikidata
View/Edit Human	View/Edit Mouse

Frizzled-6 (Fz-6) is a protein that in humans is encoded by the FZD6 gene.

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other FZD family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif. Fz-6 is believed to be the receptor for the WNT4 ligand.