Familial amyloid polyneuropathy

Familial amyloid polyneuropathy
Other namesFAP, hereditary transthyretin amyloidosis (hATTR), Corino de Andrade's disease
Familial amyloid polyneuropathy has an autosomal dominant pattern of inheritance.
SpecialtyNeurology
Diagnostic methodGenetic testing
MedicationTafamidis, patisiran

Familial amyloid polyneuropathy, also called hereditary transthyretin amyloidosis (hATTR), or Corino de Andrade's disease, is an autosomal dominant neurodegenerative disease. It is a form of amyloidosis, and was first identified and described by Portuguese neurologist Mário Corino da Costa Andrade, in 1952. FAP is distinct from senile systemic amyloidosis (SSA), which is not inherited, and which was determined to be the primary cause of death for 70% of supercentenarians who have been autopsied. FAP can be ameliorated by liver transplantation.

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