Filaggrin

FLG
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4PCW
Identifiers
Aliases	FLG, ATOD2, filaggrin
External IDs	OMIM: 135940; HomoloGene: 136751; GeneCards: FLG; OMA:FLG - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	152,325,239 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; skin of arm; ; skin of hip; ; human penis; ; vulva; ; nipple; ; skin of abdomen; ; epithelium of esophagus; ; oral cavity; ; amniotic fluid;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; protein binding; structural molecule activity; metal ion binding; transition metal ion binding; structural constituent of skin epidermis;
Cellular component	intermediate filament; keratohyalin granule; intracellular membrane-bounded organelle; nucleus; cytosol; cornified envelope; collagen-containing extracellular matrix;
Biological process	multicellular organism development; keratinocyte differentiation; establishment of skin barrier; cornification; peptide cross-linking;
	Sources:Amigo / QuickGO
Orthologs
	2312
	n/a
	ENSG00000143631
	n/a
	P20930
	n/a
	NM_002016
	n/a
	NP_002007
	n/a
	Wikidata
View/Edit Human

Filaggrin (filament aggregating protein) is a filament-associated protein that binds to keratin fibers in epithelial cells. Ten to twelve filaggrin units are post-translationally hydrolyzed from a large profilaggrin precursor protein during terminal differentiation of epidermal cells. In humans, profilaggrin is encoded by the FLG gene, which is part of the S100 fused-type protein (SFTP) family within the epidermal differentiation complex on chromosome 1q21. In cetaceans and sirenians, the FLG family has lost its function, with the curious exception of manatees in the latter clade: manatees still retain some functional FLG genes.