First South Yorkshire & Midlands
| One of First Potteries Scania Omnicitys | |
| Founded | 1999 (as First Midlands) 1 June 2020 (FSY&M) | 
|---|---|
| Headquarters | Abbey Lane, Leicester | 
| Locale | Stoke-On-Trent, Leicester, Sheffield, Doncaster | 
| Service area | English Midlands, Yorkshire and the Humber | 
| Service type | Urban and interurban bus services | 
| Operator | FirstGroup | 
| Chief executive | Rob Hughes, Operations Director | 
| Website | http://www.firstgroup.com | 
First Manchester, Midlands & South Yorkshire is an operating unit of FirstGroup operating in the English Midlands, Manchester and South Yorkshire. The unit was formed in 2008 with the merger of the management and administration of First Potteries, First Worcester and First Leicester. On 1 June 2020, First Midlands merged with First South Yorkshire. During a group restructure in 2022, Worcester moved from Midlands control to First West & Wales and Midlands & South Yorkshire integrated First Manchester.