Fluorodeoxyglucose (18F)

Fluorodeoxyglucose (¹⁸
F)
Names
	IUPAC names 2-Deoxy-2-[18; F]fluoroglucose
Identifiers
CAS Number	63503-12-8 (2S,6R)-6-meth,-2-ol ;
3D model (JSmol)	Interactive image;
Abbreviations	[18; F]FDG
Beilstein Reference	2047723
ChEBI	CHEBI:49130 ;
ChEMBL	ChEMBL497613 ;
ChemSpider	396785 ; 8096174 (2R,6R)-6-meth,-2-ol ; 9644274 (6R)-6-meth ;
KEGG	D01843 ;
PubChem CID	11469444 (6R)-6-meth; 9920539 (2R,6R)-6-meth,-2-ol; 450503 (2S,6R)-6-meth,-2-ol; 25173432 (2S)-2-ol;
UNII	0Z5B2CJX4D ;
CompTox Dashboard (EPA)	DTXSID50894178 DTXSID40212908, DTXSID50894178 ;
	InChI InChI=1S/C6H11FO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1H2/t2-,3-,4-,5-,6+/m1/s1/i7-1 Key: ZCXUVYAZINUVJD-AHXZWLDOSA-N ;
	SMILES OCC1OC(O)[C@H]([18F])[C@@H](O)[C@@H]1O;
Properties
Chemical formula	C6H1118FO5
Molar mass	181.1495 g mol−1
Melting point	170 to 176 °C (338 to 349 °F; 443 to 449 K)
Pharmacology
ATC code	V09IX04 (WHO)
Pregnancy; category	AU: X (High risk);
Routes of; administration	Intravenous
	Pharmacokinetics:
Metabolism	6-Phosphorylation; Glycolysis
Biological half-life	110 min (at 70%); 16 min (at 20%)
Excretion	20% Radioactivity renally excreted in two hours
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

[¹⁸
F]Fluorodeoxyglucose (INN), or fluorodeoxyglucose F 18 (USAN and USP), also commonly called fluorodeoxyglucose and abbreviated [¹⁸
F]FDG, 2-[¹⁸
F]FDG or FDG, is a radiopharmaceutical, specifically a radiotracer, used in the medical imaging modality positron emission tomography (PET). Chemically, it is 2-deoxy-2-[¹⁸
F]fluoro-D-glucose, a glucose analog, with the positron-emitting radionuclide fluorine-18 substituted for the normal hydroxyl group at the C-2 position in the glucose molecule.

The uptake of [¹⁸
F]FDG by tissues is a marker for the tissue uptake of glucose, which in turn is closely correlated with certain types of tissue metabolism. After [¹⁸
F]FDG is injected into a patient, a PET scanner can form two-dimensional or three-dimensional images of the distribution of [¹⁸
F]FDG within the body.

Since its development in 1976, [¹⁸
F]FDG had a profound influence on research in the neurosciences. The subsequent discovery in 1980 that [¹⁸
F]FDG accumulates in tumors underpins the evolution of PET as a major clinical tool in cancer diagnosis. [¹⁸
F]FDG is now the standard radiotracer used for PET neuroimaging and cancer patient management.

The images can be assessed by a nuclear medicine physician or radiologist to provide diagnoses of various medical conditions.

Names

IUPAC names 2-Deoxy-2-[¹⁸ F]fluoroglucose
Identifiers
CAS Number	63503-12-8 (2S,6R)-6-meth,-2-ol^Y
3D model (JSmol)	Interactive image
Abbreviations	[¹⁸ F]FDG
Beilstein Reference	2047723
ChEBI	CHEBI:49130^N
ChEMBL	ChEMBL497613^N
ChemSpider	396785^Y 8096174 (2R,6R)-6-meth,-2-ol^Y 9644274 (6R)-6-meth^Y
KEGG	D01843^N
PubChem CID	11469444 (6R)-6-meth 9920539 (2R,6R)-6-meth,-2-ol 450503 (2S,6R)-6-meth,-2-ol 25173432 (2S)-2-ol
UNII	0Z5B2CJX4D^Y
CompTox Dashboard (EPA)	DTXSID50894178 DTXSID40212908, DTXSID50894178
InChI InChI=1S/C6H11FO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1H2/t2-,3-,4-,5-,6+/m1/s1/i7-1^Y Key: ZCXUVYAZINUVJD-AHXZWLDOSA-N^Y
SMILES OCC1OC(O)[C@H]([18F])[C@@H](O)[C@@H]1O
Properties
Chemical formula	C₆H₁₁¹⁸FO₅
Molar mass	181.1495 g mol⁻¹
Melting point	170 to 176 °C (338 to 349 °F; 443 to 449 K)
Pharmacology
ATC code	V09IX04 (WHO)
Pregnancy category	AU: X (High risk)
Routes of administration	Intravenous
Pharmacokinetics:
Metabolism	6-Phosphorylation Glycolysis
Biological half-life	110 min (at 70%) 16 min (at 20%)
Excretion	20% Radioactivity renally excreted in two hours
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references