| Formylglycine-generating enzyme |
|---|
formylglycine generating enzyme c336s mutant covalently bound to substrate peptide lctpsra |
|
| Symbol | FGE-sulfatase |
|---|
| Pfam | PF03781 |
|---|
| InterPro | IPR005532 |
|---|
|
Formylglycine-generating enzyme (FGE), located at 3p26.1 in humans, is the name for an enzyme present in the endoplasmic reticulum that catalyzes the conversion of cysteine to formylglycine (fGly). There are two main classes of FGE, aerobic and anaerobic. FGE activates sulfatases, which are essential for the degradation of sulfate esters. The catalytic activity of sulfatases is dependent upon a formylglycine (sometimes called oxoalanine) residue in the active site.