| Frank Depestele | 
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| Born |  (1977-09-03) 3 September 1977 Tienen, Belgium | 
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| Height | 1.95 m (6 ft 5 in) | 
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| Weight | 93 kg (205 lb) | 
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| Spike | 332 cm (131 in) | 
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| Block | 324 cm (128 in) | 
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| Position | Setter | 
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Frank Depestele (born 3 September 1977) is a retired Belgian volleyball player and current coach. He is 1.91 m tall and played as a setter. He was a regular player on the national team of which he was also captain. He has won several different individual prizes, including that for Best Setter in the CEV Champions League and Greek Volley League MVP.