Fred DeStefano
| Date of birth | April 4, 1900 |
|---|---|
| Place of birth | Coal City, Illinois, U.S. |
| Date of death | June 27, 1974 (aged 74) |
| Place of death | Houston, Texas, U.S. |
| Career information | |
| Position(s) | Running back |
| US college | Princeton University |
| Career history | |
| As player | |
| 1924–1925 | Chicago Cardinals |
Fred DeStefano (April 4, 1900 – June 27, 1974) was a professional American football player who played running back for two seasons for the Chicago Cardinals. After retiring from football, he became a physician, and died in Houston, Texas in 1974 of multiple organ failure.