Friedländer synthesis

Friedländer synthesis
Named after Paul Friedländer
Reaction type Ring forming reaction
Identifiers
Organic Chemistry Portal friedlaender-synthesis

The Friedländer synthesis is a chemical reaction of 2-aminobenzaldehydes with ketones to form quinoline derivatives. It is named after German chemist Paul Friedländer (1857–1923).

This reaction has been catalyzed by trifluoroacetic acid, toluenesulfonic acid, iodine, and Lewis acids.

Several reviews have been published.

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