G1 and G1/S cyclins- budding yeast

< G1 and G1

Cln1, Cln2, and Cln3 are cyclin proteins expressed in the G1-phase of the cell cycle of budding yeast. Like other cyclins, they function by binding and activating cyclin-dependent kinase. They are responsible for initiating entry into a new mitotic cell cycle at Start. As described below, the G1 cyclin, Cln3, is the primary regulator of this process during normal yeast growth, with the other two G1/S cyclins performing their function upon induction by Cln3. However, Cln1 and Cln2 are also directly regulated by pathways sensing extracellular conditions, including the mating pheromone pathway.

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