G6PC

G6PC1
Identifiers
Aliases	G6PC1, glucose-6-phosphatase catalytic subunit, GSD1a, glucose-6-phosphatase catalytic subunit 1, GSD1, G6Pase, G6PC, G6PT
External IDs	OMIM: 613742; MGI: 95607; HomoloGene: 20079; GeneCards: G6PC1; OMA:G6PC1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	42,914,438 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	101,268,729 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; kidney tubule; ; buccal mucosa cell; ; jejunal mucosa; ; glomerulus; ; metanephric glomerulus; ; human kidney; ; duodenum; ; mucosa of ileum; ; renal medulla;
	Top expressed in
	right kidney; ; human kidney; ; left lobe of liver; ; gallbladder; ; proximal tubule; ; jejunum; ; epithelium of small intestine; ; duodenum; ; ileum; ; Ileal epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphate ion binding; phosphotransferase activity, alcohol group as acceptor; hydrolase activity; glucose-6-phosphatase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; integral component of endoplasmic reticulum membrane; endoplasmic reticulum;
Biological process	phosphorylated carbohydrate dephosphorylation; steroid metabolic process; glucose homeostasis; multicellular organism growth; glycogen catabolic process; urate metabolic process; lipid homeostasis; glycogen metabolic process; regulation of gene expression; response to food; phosphate-containing compound metabolic process; cholesterol homeostasis; glucose 6-phosphate metabolic process; triglyceride metabolic process; glucose-6-phosphate transport; gluconeogenesis;
	Sources:Amigo / QuickGO
Orthologs
	2538
	14377
	ENSG00000131482
	ENSMUSG00000078650
	P35575
	P35576
	NM_001270397; NM_000151
	NM_008061
	NP_000142; NP_001257326
	NP_032087
	Wikidata
View/Edit Human	View/Edit Mouse

Glucose-6-phosphatase, catalytic subunit (glucose 6-phosphatase alpha) is an enzyme that in humans is encoded by the G6PC gene.

Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate. It is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Defects in the enzyme cause glycogen storage disease type I (von Gierke disease).