GRB2-associated-binding protein 1

GAB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4QSY
Identifiers
Aliases	GAB1, GRB2 associated binding protein 1, DFNB26
External IDs	OMIM: 604439; MGI: 108088; HomoloGene: 1542; GeneCards: GAB1; OMA:GAB1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	143,474,568 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	81,607,148 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; epithelium of colon; ; endothelial cell; ; corpus callosum; ; ventricular zone; ; trigeminal ganglion; ; sural nerve; ; inferior ganglion of vagus nerve; ; spinal ganglia; ; internal globus pallidus;
	Top expressed in
	vestibular membrane of cochlear duct; ; sciatic nerve; ; vestibular sensory epithelium; ; genital tubercle; ; fossa; ; condyle; ; efferent ductule; ; external carotid artery; ; substantia nigra; ; atrioventricular junction;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Cellular component	cytosol;
Biological process	insulin receptor signaling pathway; cell population proliferation; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; ERBB2 signaling pathway; axon guidance; epidermal growth factor receptor signaling pathway; angiogenesis; actin cytoskeleton reorganization; vascular endothelial growth factor signaling pathway; positive regulation of cell migration by vascular endothelial growth factor signaling pathway; positive regulation of angiogenesis; positive regulation of protein kinase B signaling; endothelial cell chemotaxis to vascular endothelial growth factor; response to hepatocyte growth factor; positive regulation of phosphatidylinositol 3-kinase signaling;
	Sources:Amigo / QuickGO
Orthologs
	2549
	14388
	ENSG00000109458
	ENSMUSG00000031714
	Q13480
	Q9QYY0
	NM_002039; NM_207123
	NM_001301298; NM_021356
	NP_002030; NP_997006
	NP_001288227; NP_067331
	Wikidata
View/Edit Human	View/Edit Mouse

GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene.