GABRE

GABRE
Identifiers
Aliases	GABRE, gamma-aminobutyric acid type A receptor epsilon subunit, gamma-aminobutyric acid type A receptor subunit epsilon
External IDs	OMIM: 300093; HomoloGene: 68425; GeneCards: GABRE; OMA:GABRE - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	151,974,680 bp
RNA expression pattern
	Top expressed in
	vagina; ; subcutaneous adipose tissue; ; apex of heart; ; ectocervix; ; canal of the cervix; ; skin of abdomen; ; minor salivary glands; ; skin of leg; ; popliteal artery; ; tibial arteries;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	chloride channel activity; extracellular ligand-gated ion channel activity; GABA-gated chloride ion channel activity; GABA-A receptor activity; ion channel activity; transmembrane signaling receptor activity; inhibitory extracellular ligand-gated ion channel activity; benzodiazepine receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; cell junction; postsynaptic membrane; plasma membrane; synapse; membrane; chloride channel complex; GABA-A receptor complex; integral component of plasma membrane; dendrite membrane; neuron projection; postsynapse;
Biological process	ion transmembrane transport; chloride transport; chloride transmembrane transport; ion transport; negative regulation of chloride transport; signal transduction; gamma-aminobutyric acid signaling pathway; chemical synaptic transmission; regulation of membrane potential; nervous system process; synaptic transmission, GABAergic; regulation of postsynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	2564
	n/a
	ENSG00000102287
	n/a
	P78334
	n/a
	NM_004961; NM_021984; NM_021987; NM_021990
	n/a
	NP_004952
	n/a
	Wikidata
View/Edit Human

Gamma-aminobutyric acid receptor subunit epsilon is a protein that in humans is encoded by the GABRE gene.

The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants encoding different isoforms have been identified.

Brainstem expression of ε subunit-containing GABA_A receptors is upregulated during pregnancy, particularly in the ventral respiratory group.