GABRG1

GABRG1
Identifiers
Aliases	GABRG1, gamma-aminobutyric acid type A receptor gamma1 subunit, gamma-aminobutyric acid type A receptor subunit gamma1
External IDs	OMIM: 137166; MGI: 103156; HomoloGene: 22570; GeneCards: GABRG1; OMA:GABRG1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	46,124,054 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	70,999,960 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; endothelial cell; ; external globus pallidus; ; Brodmann area 23; ; entorhinal cortex; ; caudate nucleus; ; nucleus accumbens; ; Amygdala; ; Brodmann area 46; ; Hypothalamus;
	Top expressed in
	paraventricular nucleus of hypothalamus; ; ventromedial nucleus; ; lateral septal nucleus; ; dorsomedial hypothalamic nucleus; ; arcuate nucleus; ; suprachiasmatic nucleus; ; median eminence; ; lateral hypothalamus; ; globus pallidus; ; mammillary body;
	More reference expression data
	n/a
Gene ontology
Molecular function	chloride channel activity; extracellular ligand-gated ion channel activity; GABA-A receptor activity; ion channel activity; transmembrane signaling receptor activity; GABA receptor binding; inhibitory extracellular ligand-gated ion channel activity; benzodiazepine receptor activity; GABA-gated chloride ion channel activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; cell junction; postsynaptic membrane; plasma membrane; receptor complex; synapse; membrane; chloride channel complex; integral component of plasma membrane; dendrite membrane; neuron projection; postsynapse; GABA-A receptor complex;
Biological process	gamma-aminobutyric acid signaling pathway; ion transmembrane transport; chloride transport; chloride transmembrane transport; ion transport; chemical synaptic transmission; signal transduction; regulation of membrane potential; nervous system process; synaptic transmission, GABAergic; regulation of postsynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	2565
	14405
	ENSG00000163285
	ENSMUSG00000001260
	Q8N1C3
	Q9R0Y8
	NM_173536
	NM_010252
	NP_775807
	NP_034382
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-aminobutyric acid receptor subunit gamma-1 is a protein that in humans is encoded by the GABRG1 gene. The protein encoded by this gene is a subunit of the GABAA receptor.

Variants of this gene may be associated with alcohol dependence.