GABRP

GABRP
Identifiers
Aliases	GABRP, gamma-aminobutyric acid type A receptor pi subunit, gamma-aminobutyric acid type A receptor subunit pi
External IDs	OMIM: 602729; MGI: 2387597; HomoloGene: 22798; GeneCards: GABRP; OMA:GABRP - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	170,814,047 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	33,528,959 bp
RNA expression pattern
	Top expressed in
	nasal epithelium; ; epithelium of nasopharynx; ; palpebral conjunctiva; ; olfactory zone of nasal mucosa; ; endometrium; ; epithelium of lactiferous gland; ; lactiferous duct; ; mucosa of paranasal sinus; ; amniotic fluid; ; epithelium of bronchus;
	Top expressed in
	trachea; ; right lung lobe; ; olfactory epithelium; ; genital tubercle; ; abdominal wall; ; gastrula; ; secondary oocyte; ; seminal vesicula; ; lip; ; skin of abdomen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	extracellular ligand-gated ion channel activity; chloride channel activity; GABA-A receptor activity; ion channel activity; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; cell junction; postsynaptic membrane; plasma membrane; synapse; membrane; chloride channel complex; GABA-A receptor complex; integral component of plasma membrane; neuron projection;
Biological process	ion transmembrane transport; chloride transport; ion transport; signal transduction; chloride transmembrane transport; chemical synaptic transmission; regulation of membrane potential; nervous system process;
	Sources:Amigo / QuickGO
Orthologs
	2568
	216643
	ENSG00000094755
	ENSMUSG00000020159
	O00591
	Q8QZW7
	NM_001291985; NM_014211
	NM_146017
	NP_001278914; NP_055026
	NP_666129
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-aminobutyric acid receptor subunit pi is a protein that in humans is encoded by the GABRP gene.

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.