GADD45A

GADD45A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KG4
Identifiers
Aliases	GADD45A, DDIT1, GADD45, growth arrest and DNA damage inducible alpha
External IDs	OMIM: 126335; MGI: 107799; HomoloGene: 1449; GeneCards: GADD45A; OMA:GADD45A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	67,688,334 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	67,014,441 bp
RNA expression pattern
	Top expressed in
	Descending thoracic aorta; ; vena cava; ; ascending aorta; ; popliteal artery; ; tibial arteries; ; glomerulus; ; metanephric glomerulus; ; human kidney; ; cartilage tissue; ; left coronary artery;
	Top expressed in
	granulocyte; ; muscle of thigh; ; blood; ; extensor digitorum longus muscle; ; fetal liver hematopoietic progenitor cell; ; transitional epithelium of urinary bladder; ; renal corpuscle; ; interventricular septum; ; duodenum; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; kinase binding; protein homodimerization activity; protein heterodimerization activity; protein N-terminus binding; RNA polymerase II core promoter sequence-specific DNA binding;
Cellular component	cytoplasm; nucleus; nucleoplasm; nuclear speck;
Biological process	apoptotic process; centrosome cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of protein kinase activity; signal transduction in response to DNA damage; response to stress; positive regulation of JNK cascade; regulation of cell cycle; cellular response to DNA damage stimulus; cellular response to mechanical stimulus; positive regulation of reactive oxygen species metabolic process; positive regulation of apoptotic process; cellular response to ionizing radiation; cell cycle; DNA repair; positive regulation of p38MAPK cascade; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;
	Sources:Amigo / QuickGO
Orthologs
	1647
	13197
	ENSG00000116717
	ENSMUSG00000036390
	P24522
	P48316
	NM_001924; NM_001199741; NM_001199742
	NM_007836
	NP_001186670; NP_001186671; NP_001915
	NP_031862
	Wikidata
View/Edit Human	View/Edit Mouse

Growth arrest and DNA-damage-inducible protein GADD45 alpha is a protein that in humans is encoded by the GADD45A gene.