Galactokinase

Galactokinase 1
Cartoon structure of a human galactokinase 1 monomer in complex with galactose (red) and an ATP analogue (orange). A magnesium ion is visible as a green sphere. (From PDB: 1WUU​)
Identifiers
SymbolGALK1
Alt. symbolsGALK
NCBI gene2584
HGNC4118
OMIM604313
RefSeqNM_000154
UniProtP51570
Other data
EC number2.7.1.6
LocusChr. 17 q23-q25
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StructuresSwiss-model
DomainsInterPro
Galactokinase 2
Identifiers
SymbolGALK2
NCBI gene2585
HGNC4119
OMIM137028
RefSeqNM_002044
UniProtQ01415
Other data
EC number2.7.1.6
LocusChr. 15
Search for
StructuresSwiss-model
DomainsInterPro

Galactokinase is an enzyme (phosphotransferase) that facilitates the phosphorylation of α-D-galactose to galactose 1-phosphate at the expense of one molecule of ATP. Galactokinase catalyzes the second step of the Leloir pathway, a metabolic pathway found in most organisms for the catabolism of α-D-galactose to glucose 1-phosphate. First isolated from mammalian liver, galactokinase has been studied extensively in yeast, archaea, plants, and humans.

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