GALNT1

GALNT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XHB
Identifiers
Aliases	GALNT1, GALNAC-T1, polypeptide N-acetylgalactosaminyltransferase 1
External IDs	OMIM: 602273; MGI: 894693; HomoloGene: 8469; GeneCards: GALNT1; OMA:GALNT1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	35,711,834 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	24,419,875 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; mucosa of pharynx; ; nipple; ; amniotic fluid; ; oral cavity; ; tibia; ; superior surface of tongue; ; lactiferous duct; ; retinal pigment epithelium; ; periodontal fiber;
	Top expressed in
	endothelial cell of lymphatic vessel; ; molar; ; blood; ; proximal tubule; ; right kidney; ; cardiac muscle tissue of left ventricle; ; parotid gland; ; decidua; ; fossa; ; ciliary body;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	glycosyltransferase activity; polypeptide N-acetylgalactosaminyltransferase activity; transferase activity; manganese ion binding; metal ion binding; carbohydrate binding;
Cellular component	perinuclear region of cytoplasm; integral component of membrane; extracellular region; Golgi cisterna membrane; Golgi membrane; Golgi apparatus; membrane; endoplasmic reticulum membrane;
Biological process	protein glycosylation; protein O-linked glycosylation via serine; protein O-linked glycosylation via threonine; O-glycan processing; protein O-linked glycosylation;
	Sources:Amigo / QuickGO
Orthologs
	2589
	14423
	ENSG00000141429
	ENSMUSG00000000420
	Q10472
	O08912
	NM_020474
	NM_001160404; NM_013814; NM_001361200
	NP_065207
	NP_001153876; NP_038842; NP_001348129
	Wikidata
View/Edit Human	View/Edit Mouse

Polypeptide N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the GALNT1 gene.

This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. Transcript variants derived from this gene that utilize alternative polyA signals have been described in the literature.