GALNT2

GALNT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FFU, 2FFV, 4D0T, 4D0Z, 4D11, 5AJN, 5AJO, 5AJP, 5FV9
Identifiers
Aliases	GALNT2, GalNAc-T2, polypeptide N-acetylgalactosaminyltransferase 2, CDG2T
External IDs	OMIM: 602274; MGI: 894694; HomoloGene: 3297; GeneCards: GALNT2; OMA:GALNT2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	230,282,122 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	125,072,463 bp
RNA expression pattern
	Top expressed in
	Descending thoracic aorta; ; ascending aorta; ; cartilage tissue; ; gastric mucosa; ; right coronary artery; ; stromal cell of endometrium; ; body of pancreas; ; palpebral conjunctiva; ; right lobe of liver; ; left coronary artery;
	Top expressed in
	lens; ; yolk sac; ; pancreas; ; stomach; ; islet of Langerhans; ; proximal tubule; ; neural tube; ; Mesencephalon; ; skeletal muscle tissue; ; right kidney;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; manganese ion binding; glycosyltransferase activity; metal ion binding; protein binding; carbohydrate binding; polypeptide N-acetylgalactosaminyltransferase activity;
Cellular component	integral component of membrane; integral component of Golgi membrane; Golgi apparatus; membrane; Golgi membrane; extracellular region; Golgi cisterna membrane; perinuclear region of cytoplasm; Golgi stack; extracellular exosome; endoplasmic reticulum membrane;
Biological process	protein O-linked glycosylation via serine; protein glycosylation; protein O-linked glycosylation via threonine; O-glycan processing; protein O-linked glycosylation;
	Sources:Amigo / QuickGO
Orthologs
	2590
	108148
	ENSG00000143641
	ENSMUSG00000089704
	Q10471
	Q6PB93
	NM_001291866; NM_004481
	NM_139272
	NP_001278795; NP_004472
	NP_644678
	Wikidata
View/Edit Human	View/Edit Mouse

Polypeptide N-acetylgalactosaminyltransferase 2 is an enzyme that in humans is encoded by the GALNT2 gene.

This gene encodes polypeptide N-acetylgalactosaminyltransferase 2, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. The localization site of this particular enzyme is preponderantly the trans-Golgi. Individual GalNAc-transferases have distinct activities, and initiation of O-glycosylation in a cell is regulated by a repertoire of GalNAc-transferases.