Gap-43 protein

GAP43
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4E53
Identifiers
Aliases	GAP43, B-50, PP46, growth associated protein 43, GAP-43
External IDs	OMIM: 162060; MGI: 95639; HomoloGene: 1545; GeneCards: GAP43; OMA:GAP43 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	115,721,490 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	42,161,014 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; frontal pole; ; Brodmann area 23; ; right frontal lobe; ; dorsolateral prefrontal cortex; ; superior frontal gyrus; ; orbitofrontal cortex; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	superior cervical ganglion; ; ventromedial nucleus; ; ventral tegmental area; ; lateral hypothalamus; ; lateral septal nucleus; ; anterior amygdaloid area; ; paraventricular nucleus of hypothalamus; ; dorsomedial hypothalamic nucleus; ; arcuate nucleus; ; nucleus of stria terminalis;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	lysophosphatidic acid binding; phosphatidylinositol phosphate binding; phosphatidylserine binding; calmodulin binding; protein binding;
Cellular component	cytoplasm; cell projection; membrane; postsynaptic density; growth cone membrane; synapse; axon; cell junction; cell periphery; filopodium membrane; plasma membrane; GABA-ergic synapse;
Biological process	regulation of filopodium assembly; cell differentiation; cell fate commitment; tissue regeneration; glial cell differentiation; nervous system development; multicellular organism development; protein kinase C-activating G protein-coupled receptor signaling pathway; response to wounding; regulation of growth; axon choice point recognition; axon development; axon guidance; regulation of postsynaptic specialization assembly; axon regeneration;
	Sources:Amigo / QuickGO
Orthologs
	2596
	14432
	ENSG00000172020
	ENSMUSG00000047261
	P17677
	P06837
	NM_002045; NM_001130064
	NM_008083
	NP_001123536; NP_002036
	NP_032109
	Wikidata
View/Edit Human	View/Edit Mouse

Growth Associated Protein 43 (GAP43) is a protein encoded by the GAP43 gene in humans.

GAP43 is called a "growth" or "plasticity" protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration, and it is phosphorylated after long-term potentiation and after learning.

GAP43 is a crucial component of the axon and presynaptic terminal. Its null mutation leads to death within days after birth, due to axon pathfinding defects.