Glycine—tRNA ligase

GARS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2PME, 2PMF, 2Q5H, 2Q5I, 2ZT5, 2ZT6, 2ZT7, 2ZT8, 2ZXF, 4KQE, 4KR2, 4QEI, 5E6M
Identifiers
Aliases	GARS1, CMT2D, DSMAV, GlyRS, HMN5, SMAD1, glycyl-tRNA synthetase, GARS, glycyl-tRNA synthetase 1, HMN5A, SMAJI
External IDs	OMIM: 600287; MGI: 2449057; HomoloGene: 1547; GeneCards: GARS1; OMA:GARS1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	30,634,033 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	55,056,485 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; cartilage tissue; ; lateral nuclear group of thalamus; ; middle temporal gyrus; ; tibia; ; spinal ganglia; ; pars compacta; ; stromal cell of endometrium; ; islet of Langerhans; ; mucosa of pharynx;
	Top expressed in
	somite; ; fetal liver hematopoietic progenitor cell; ; epiblast; ; endocardial cushion; ; maxillary prominence; ; primitive streak; ; mandibular prominence; ; facial motor nucleus; ; Paneth cell; ; calvaria;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	aminoacyl-tRNA ligase activity; nucleotide binding; ligase activity; protein dimerization activity; ATP binding; bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity; hydrolase activity; protein binding; identical protein binding; glycine-tRNA ligase activity; transferase activity;
Cellular component	axon; mitochondrial matrix; cell projection; secretory granule; cytosol; extracellular exosome; extracellular region; cytoplasm; mitochondrion;
Biological process	diadenosine tetraphosphate biosynthetic process; protein biosynthesis; glycyl-tRNA aminoacylation; mitochondrial glycyl-tRNA aminoacylation; tRNA aminoacylation for protein translation;
	Sources:Amigo / QuickGO
Orthologs
	2617
	353172
	ENSG00000106105
	ENSMUSG00000029777
	P41250
	Q9CZD3
	NM_002047; NM_001316772
	NM_180678
	NP_001303701; NP_002038
	NP_851009
	Wikidata
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Glycine—tRNA ligase
Glycine—tRNA ligase
Identifiers
EC no.	6.1.1.14
CAS no.	9037-62-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

Glycine—tRNA ligase also known as glycyl–tRNA synthetase is an enzyme that in humans is encoded by the GARS1 gene.