GAS2

GAS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1V5R
Identifiers
Aliases	GAS2, growth arrest specific 2, GAS-2
External IDs	OMIM: 602835; MGI: 95657; HomoloGene: 31301; GeneCards: GAS2; OMA:GAS2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	22,813,001 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	51,644,723 bp
RNA expression pattern
	Top expressed in
	trigeminal ganglion; ; liver; ; sural nerve; ; right lobe of liver; ; islet of Langerhans; ; C1 segment; ; Skeletal muscle tissue of rectus abdominis; ; Achilles tendon; ; gonad; ; spinal ganglia;
	Top expressed in
	vestibular sensory epithelium; ; stria vascularis; ; vestibular membrane of cochlear duct; ; right kidney; ; proximal tubule; ; utricle; ; human kidney; ; hand; ; cochlea; ; saccule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	microtubule binding; actin binding;
Cellular component	cytoskeleton; cytosol; actin filament; membrane; cytoplasm;
Biological process	cell cycle; regulation of cell shape; apoptotic process; initiation of primordial ovarian follicle growth; antral ovarian follicle growth; regulation of Notch signaling pathway; ovulation; basement membrane organization; microtubule cytoskeleton organization; actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	2620
	14453
	ENSG00000148935
	ENSMUSG00000030498
	O43903
	P11862
NM_001143830; NM_005256; NM_177553; NM_001351224; NM_001391933;
	NM_001391934; NM_001391935; NM_001391936; NM_001391937
	NM_008087; NM_001330607; NM_001330608
	NP_001137302; NP_005247; NP_808221; NP_001338153
	NP_001317536; NP_001317537; NP_032113
	Wikidata
View/Edit Human	View/Edit Mouse

Growth arrest-specific protein 2 is a protein that in humans is encoded by the GAS2 gene.

The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.