GATA4

GATA4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M9W
Identifiers
Aliases	GATA4, GATA binding protein 4, ASD2, TACHD, VSD1, TOF
External IDs	OMIM: 600576; MGI: 95664; HomoloGene: 1551; GeneCards: GATA4; OMA:GATA4 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	11,760,002 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	63,509,141 bp
RNA expression pattern
	Top expressed in
	right auricle of heart; ; left ventricle; ; duodenum; ; apex of heart; ; left ovary; ; right coronary artery; ; right ovary; ; body of pancreas; ; left coronary artery; ; right testis;
	Top expressed in
	epithelium of stomach; ; germinal epithelium; ; pyloric antrum; ; duodenum; ; granulosa cell of ovary; ; mucous cell of stomach; ; Gonadal ridge; ; Leydig cell; ; theca folliculi; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; co-SMAD binding; DNA-binding transcription factor activity; transcription coactivator activity; zinc ion binding; transcription factor binding; chromatin binding; metal ion binding; protein binding; cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein kinase binding; NFAT protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	nucleoplasm; RNA polymerase II transcription regulator complex; nucleus; nuclear body;
Biological process	endoderm development; male gonad development; regulation of transcription, DNA-templated; ventricular septum development; cell growth involved in cardiac muscle cell development; embryonic foregut morphogenesis; endocardial cushion development; cardiac muscle cell differentiation; cell-cell signaling; response to mechanical stimulus; blood coagulation; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of angiogenesis; positive regulation of transcription, DNA-templated; heart looping; atrial septum morphogenesis; response to vitamin A; regulation of cardiac muscle cell contraction; atrial septum secundum morphogenesis; atrial septum primum morphogenesis; intestinal epithelial cell differentiation; embryonic heart tube anterior/posterior pattern specification; positive regulation of BMP signaling pathway; positive regulation of cardioblast differentiation; positive regulation of vascular endothelial growth factor production; negative regulation of autophagy; cardiac ventricle morphogenesis; cardiac right ventricle morphogenesis; cellular response to glucose stimulus; positive regulation of transcription by RNA polymerase II; transdifferentiation; aortic valve morphogenesis; heart development; animal organ morphogenesis; tissue development; cell development; anatomical structure formation involved in morphogenesis; digestive tract development; cardiac muscle tissue development; atrioventricular valve formation; negative regulation of cardiac muscle cell apoptotic process; regulation of protein kinase B signaling; cardiac muscle tissue regeneration; positive regulation of ERK1 and ERK2 cascade; negative regulation of oxidative stress-induced cell death; negative regulation of apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2626
	14463
	ENSG00000136574; ENSG00000285109
	ENSMUSG00000021944
	P43694
	Q08369
	NM_001308093; NM_001308094; NM_002052; NM_001374273; NM_001374274
	NM_008092; NM_001310610
	NP_001295022; NP_001295023; NP_002043; NP_001361202; NP_001361203
	NP_001297539; NP_032118
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor GATA-4 is a protein that in humans is encoded by the GATA4 gene.