GATA6

GATA6
Identifiers
Aliases	GATA6, GATA binding protein 6
External IDs	OMIM: 601656; MGI: 107516; HomoloGene: 68449; GeneCards: GATA6; OMA:GATA6 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	22,202,528 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	11,085,635 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; parietal pleura; ; jejunal mucosa; ; pylorus; ; right ventricle; ; cardiac muscle tissue of right atrium; ; right ovary; ; left ovary; ; lower lobe of lung; ; left adrenal gland;
	Top expressed in
	atrium; ; atrioventricular valve; ; epithelium of stomach; ; endocardial cushion; ; right ventricle; ; pyloric antrum; ; migratory enteric neural crest cell; ; morula; ; semi-lunar valve; ; septum transversum;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; zinc ion binding; transcription factor binding; chromatin binding; metal ion binding; protein binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; cis-regulatory region sequence-specific DNA binding;
Cellular component	transcription regulator complex; nucleoplasm; nucleus; nuclear membrane;
Biological process	club cell differentiation; male gonad development; regulation of transcription, DNA-templated; epithelial cell differentiation; endodermal cell differentiation; negative regulation of transforming growth factor beta1 production; cardiac muscle tissue development; pancreatic A cell differentiation; cardiac muscle cell differentiation; cardiac vascular smooth muscle cell differentiation; cellular response to BMP stimulus; endodermal cell fate determination; blood coagulation; in utero embryonic development; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; negative regulation of transforming growth factor beta2 production; tube morphogenesis; negative regulation of apoptotic process; smooth muscle cell differentiation; transcription, DNA-templated; positive regulation of angiogenesis; outflow tract septum morphogenesis; response to estrogen; animal organ formation; positive regulation of cardiac muscle cell proliferation; cardiac muscle hypertrophy in response to stress; intestinal epithelial cell differentiation; positive regulation of BMP signaling pathway; positive regulation of cardioblast differentiation; regulation of gene expression; phospholipid metabolic process; liver development; pancreas development; response to growth factor; type II pneumocyte differentiation; lung saccule development; negative regulation of transcription, DNA-templated; cellular response to hypoxia; type B pancreatic cell differentiation; cellular response to gonadotropin stimulus; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of cardiac muscle myoblast proliferation; heart development; animal organ morphogenesis; tissue development; cell development; anatomical structure formation involved in morphogenesis; digestive tract development;
	Sources:Amigo / QuickGO
Orthologs
	2627
	14465
	ENSG00000141448
	ENSMUSG00000005836
	Q92908
	Q61169
	NM_005257
	NM_010258
	NP_005248
	NP_034388
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor GATA-6, also known as GATA-binding factor 6 (GATA6), is protein that in humans is encoded by the GATA6 gene. The gene product preferentially binds (A/T/C)GAT(A/T)(A) of the consensus binding sequence.