GCFC2

GCFC2
Identifiers
Aliases	GCFC2, C2orf3, DNABF, GCF, TCF9, GC-rich sequence DNA-binding factor 2
External IDs	OMIM: 189901; MGI: 2141656; HomoloGene: 2411; GeneCards: GCFC2; OMA:GCFC2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	75,710,985 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	81,959,915 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; gastrocnemius muscle; ; right lobe of liver; ; Achilles tendon; ; muscle of thigh; ; canal of the cervix; ; right uterine tube; ; body of pancreas; ; gonad; ; ectocervix;
	Top expressed in
	hand; ; superior cervical ganglion; ; tail of embryo; ; otolith organ; ; utricle; ; foot; ; epiblast; ; genital tubercle; ; Rostral migratory stream; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding;
Cellular component	nucleolus; nucleus; U2-type post-mRNA release spliceosomal complex; nucleoplasm; cytosol;
Biological process	mRNA processing; spliceosomal complex assembly; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; RNA splicing; mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	6936
	330361
	ENSG00000005436
	ENSMUSG00000035125
	P16383
	Q8BKT3
	NM_001201334; NM_001201335; NM_003203
	NM_177884
	NP_001188263; NP_001188264; NP_003194
	NP_808552
	Wikidata
View/Edit Human	View/Edit Mouse

GC-rich sequence DNA-binding factor is a protein that in humans is encoded by the GCFC2 gene.

The first mRNA transcript isolated for this gene was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204). A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA, thus mistakenly thought to identify a transcription factor gene.