GTP cyclohydrolase I

GCH1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1FB1

Identifiers

GCH1, DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B, GTP cyclohydrolase 1

External IDs

OMIM: 600225; MGI: 95675; HomoloGene: 132; GeneCards: GCH1; OMA:GCH1 - orthologs

Gene location (Human)

Chr.	Chromosome 14 (human)

Band	14q22.2	Start	54,842,008 bp
Band	14q22.2	End	54,902,826 bp

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)

Band	14 C1\|14 24.6 cM	Start	47,391,352 bp
Band	14 C1\|14 24.6 cM	End	47,426,870 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

beta cell

jejunal mucosa

kidney tubule

cartilage tissue

palpebral conjunctiva

mononuclear cell

monocyte

epithelium of nasopharynx

right lobe of liver

Top expressed in

superior cervical ganglion

pineal gland

left lobe of liver

islet of Langerhans

zygote

gastrula

pyloric antrum

secondary oocyte

cumulus cell

tibiofemoral joint

More reference expression data


More reference expression data

Gene ontology
Molecular function	nucleotide binding calcium ion binding protein homodimerization activity zinc ion binding GTP binding metal ion binding protein binding catalytic activity hydrolase activity GTP cyclohydrolase I activity mitogen-activated protein kinase binding GTPase activity GTP-dependent protein binding translation initiation factor binding
Cellular component	cytoplasm cytosol nuclear membrane nucleoplasm cytoplasmic vesicle nucleus neuron projection terminus protein-containing complex
Biological process	nitric oxide biosynthetic process response to interferon-gamma neuromuscular process controlling posture protein heterooligomerization negative regulation of blood pressure dopamine biosynthetic process regulation of lung blood pressure vasodilation pteridine-containing compound biosynthetic process 7,8-dihydroneopterin 3'-triphosphate biosynthetic process dihydrobiopterin metabolic process regulation of blood pressure response to tumor necrosis factor tetrahydrofolate biosynthetic process response to lipopolysaccharide positive regulation of nitric-oxide synthase activity response to pain tetrahydrobiopterin biosynthetic process metabolism protein homooligomerization regulation of removal of superoxide radicals positive regulation of heart rate protein-containing complex assembly
Sources:Amigo / QuickGO

Species

Human

Mouse


2643


14528


ENSG00000131979


ENSMUSG00000037580


P30793


Q05915

RefSeq (mRNA)


NM_000161 NM_001024024 NM_001024070 NM_001024071


NM_008102

RefSeq (protein)


NP_000152 NP_001019195 NP_001019241 NP_001019242


NP_032128

Location (UCSC)

Chr 14: 54.84 – 54.9 Mb

Chr 14: 47.39 – 47.43 Mb

PubMed search

View/Edit Human

View/Edit Mouse

GTP cyclohydrolase I (GTPCH) (EC 3.5.4.16) is a member of the GTP cyclohydrolase family of enzymes. GTPCH is part of the folate and biopterin biosynthesis pathways. It is responsible for the hydrolysis of guanosine triphosphate (GTP) to form 7,8-dihydroneopterin triphosphate (7,8-DHNP-3'-TP, 7,8-NH₂-3'-TP).