GCHFR

GCHFR
Identifiers
Aliases	GCHFR, GFRP, HsT16933, P35, GTP cyclohydrolase I feedback regulator
External IDs	OMIM: 602437; MGI: 2443977; HomoloGene: 3849; GeneCards: GCHFR; OMA:GCHFR - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	40,767,708 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	119,002,871 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; olfactory zone of nasal mucosa; ; mucosa of transverse colon; ; right lung; ; jejunal mucosa; ; mucosa of ileum; ; duodenum; ; human kidney; ; upper lobe of left lung; ; oral cavity;
	Top expressed in
	right kidney; ; left lobe of liver; ; proximal tubule; ; olfactory epithelium; ; jejunum; ; interventricular septum; ; embryo; ; blood; ; lobe of prostate; ; human kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTP cyclohydrolase binding; enzyme inhibitor activity; amino acid binding; protein binding; enzyme binding; GTP-dependent protein binding;
Cellular component	cytoplasm; cytosol; nuclear membrane; membrane; melanosome; dendrite; nucleus; nucleoplasm; protein-containing complex;
Biological process	nitric oxide biosynthetic process; protein heterooligomerization; negative regulation of GTP cyclohydrolase I activity; neurotransmitter metabolic process; negative regulation of biosynthetic process; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	2644
	320415
	ENSG00000137880
	ENSMUSG00000046814
	P30047
	P99025
	NM_005258
	NM_177157
	NP_005249
	NP_796131
	Wikidata
View/Edit Human	View/Edit Mouse

GTP cyclohydrolase 1 feedback regulatory protein is an enzyme that in humans is encoded by the GCHFR gene.

GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.