Glucokinase regulatory protein
| glucokinase (hexokinase 4) regulator | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | GCKR | ||||||
| NCBI gene | 2646 | ||||||
| HGNC | 4196 | ||||||
| OMIM | 600842 | ||||||
| RefSeq | NM_001486 | ||||||
| UniProt | Q14397 | ||||||
| Other data | |||||||
| Locus | Chr. 2 p23 | ||||||
| |||||||
The glucokinase regulatory protein (GKRP) also known as glucokinase (hexokinase 4) regulator (GCKR) is a protein produced in hepatocytes (liver cells). GKRP binds and moves glucokinase (GK), thereby controlling both activity and intracellular location of this key enzyme of glucose metabolism. GKRP has also been proposed as one of the fructose-sensing receptors and glucokinase as one of its signal transducers.
GKRP is a 68 kD protein of 626 amino acids. It is coded for by a 19 exon gene, GCKR, on the short arm of chromosome 2 (2p23). GKRP was discovered by Emile van Schaftingen and reported in 1989.