GCLC

GCLC
Identifiers
Aliases	GCLC, GCL, GCS, GLCL, GLCLC, glutamate-cysteine ligase catalytic subunit
External IDs	OMIM: 606857; MGI: 104990; HomoloGene: 1148; GeneCards: GCLC; OMA:GCLC - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	53,616,970 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	77,701,767 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; right uterine tube; ; olfactory zone of nasal mucosa; ; gingival epithelium; ; liver; ; nasal epithelium; ; islet of Langerhans; ; epithelium of colon; ; jejunal mucosa; ; right lobe of liver;
	Top expressed in
	epithelium of stomach; ; left lobe of liver; ; right lung lobe; ; right kidney; ; seminal vesicula; ; human kidney; ; epithelium of lens; ; transitional epithelium of urinary bladder; ; stroma of bone marrow; ; proximal tubule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ADP binding; ligase activity; glutamate-cysteine ligase activity; protein heterodimerization activity; ATP binding; magnesium ion binding; glutamate binding; catalytic activity;
Cellular component	cytosol; glutamate-cysteine ligase complex;
Biological process	negative regulation of neuron apoptotic process; response to drug; glutathione metabolic process; cysteine metabolic process; negative regulation of extrinsic apoptotic signaling pathway; response to heat; negative regulation of apoptotic process; response to arsenic-containing substance; response to oxidative stress; cell redox homeostasis; regulation of mitochondrial depolarization; negative regulation of protein ubiquitination; apoptotic mitochondrial changes; response to nitrosative stress; response to hormone; glutamate metabolic process; negative regulation of transcription, DNA-templated; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; L-ascorbic acid metabolic process; cellular response to insulin stimulus; ageing; negative regulation of hepatic stellate cell activation; cellular response to thyroxine stimulus; cellular response to follicle-stimulating hormone stimulus; cellular response to fibroblast growth factor stimulus; response to human chorionic gonadotropin; response to interleukin-1; cellular response to mechanical stimulus; response to nutrient; response to activity; response to cadmium ion; cellular response to hepatocyte growth factor stimulus; cellular response to glucose stimulus; glutathione biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	2729
	14629
	ENSG00000001084
	ENSMUSG00000032350
	P48506
	P97494
	NM_001498; NM_001197115
	NM_010295
	NP_001184044; NP_001489
	NP_034425
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamate–cysteine ligase catalytic subunit is an enzyme that in humans is encoded by the GCLC gene.