GCLM

GCLM
Identifiers
Aliases	GCLM, GLCLR, glutamate-cysteine ligase modifier subunit
External IDs	OMIM: 601176; MGI: 104995; HomoloGene: 1557; GeneCards: GCLM; OMA:GCLM - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	93,909,456 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	122,064,381 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; islet of Langerhans; ; jejunal mucosa; ; hair follicle; ; secondary oocyte; ; cartilage tissue; ; Skeletal muscle tissue of rectus abdominis; ; epithelium of nasopharynx; ; duodenum; ; trabecular bone;
	Top expressed in
	right kidney; ; stroma of bone marrow; ; blood; ; fetal liver hematopoietic progenitor cell; ; left lobe of liver; ; human kidney; ; tibiofemoral joint; ; pyloric antrum; ; lacrimal gland; ; facial motor nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	enzyme regulator activity; glutamate-cysteine ligase catalytic subunit binding; protein heterodimerization activity; glutamate-cysteine ligase activity;
Cellular component	cytosol; glutamate-cysteine ligase complex;
Biological process	negative regulation of neuron apoptotic process; glutathione metabolic process; cysteine metabolic process; negative regulation of extrinsic apoptotic signaling pathway; regulation of mitochondrial depolarization; apoptotic mitochondrial changes; response to nitrosative stress; glutamate metabolic process; glutathione biosynthetic process; positive regulation of glutamate-cysteine ligase activity; response to oxidative stress; ageing; cellular response to thyroxine stimulus; hepatic stellate cell activation; cellular response to follicle-stimulating hormone stimulus; cellular response to fibroblast growth factor stimulus; response to human chorionic gonadotropin; response to nutrient; response to activity; cellular response to hepatocyte growth factor stimulus; cellular response to glucose stimulus; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	2730
	14630
	ENSG00000023909
	ENSMUSG00000028124
	P48507
	O09172
	NM_001308253; NM_002061
	NM_008129
	NP_001295182; NP_002052
	NP_032155
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamate-cysteine ligase regulatory subunit is an enzyme that in humans is encoded by the GCLM gene.

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.