GCM1

GCM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ODH
Identifiers
Aliases	GCM1, GCMA, hGCMa, glial cells missing homolog 1, glial cells missing transcription factor 1
External IDs	OMIM: 603715; MGI: 108045; HomoloGene: 2702; GeneCards: GCM1; OMA:GCM1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	53,148,841 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	77,972,906 bp
RNA expression pattern
	Top expressed in
	placenta; ; decidua; ; testicle; ; sperm; ; blood; ; kidney tubule; ; human kidney; ; islet of Langerhans; ; white blood cell; ; metanephros;
	Top expressed in
	syncytiotrophoblast; ; embryo; ; proximal tubule; ; right kidney; ; yolk sac; ; trophoblast giant cell; ; lumbar spinal ganglion; ; human kidney; ; metanephros;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; zinc ion binding; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; histone deacetylase binding; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	transcription regulator complex; nucleus;
Biological process	regulation of transcription, DNA-templated; anatomical structure morphogenesis; positive regulation of syncytium formation by plasma membrane fusion; transcription by RNA polymerase II; transcription, DNA-templated; multicellular organism development; branching involved in labyrinthine layer morphogenesis; astrocyte fate commitment; positive regulation of transcription by RNA polymerase II; gliogenesis; regulation of cell differentiation involved in embryonic placenta development; cell differentiation involved in embryonic placenta development;
	Sources:Amigo / QuickGO
Orthologs
	8521
	14531
	ENSG00000137270
	ENSMUSG00000023333
	Q9NP62
	P70348
	NM_003643
	NM_008103
	NP_003634
	NP_032129
	Wikidata
View/Edit Human	View/Edit Mouse

Chorion-specific transcription factor GCMa is a protein that, in humans, is encoded by the GCM1 gene.

This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.

In cancer patients, GCM1 expression has been linked to both higher and lower survival rates, depending on cancer type.