GCM2

GCM2
Identifiers
Aliases	GCM2, GCMB, hGCMb, glial cells missing homolog 2, HRPT4, glial cells missing transcription factor 2, FIH2
External IDs	OMIM: 603716; MGI: 1861438; HomoloGene: 3490; GeneCards: GCM2; OMA:GCM2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	10,882,041 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	41,264,511 bp
RNA expression pattern
	Top expressed in
	testicle; ; embryo; ; sperm; ; ganglionic eminence; ; left testis; ; right testis; ; stomach; ; body of stomach;
	Top expressed in
	secondary oocyte; ; zygote; ; primary oocyte; ; urethra; ; male urethra; ; Ileal epithelium; ; parathyroid; ; piriform cortex; ; primary motor cortex; ; inferior colliculi;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; metal ion binding; DNA-binding transcription activator activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	transcription, DNA-templated; parathyroid gland development; cellular phosphate ion homeostasis; regulation of transcription, DNA-templated; cellular calcium ion homeostasis; multicellular organism development; gliogenesis; positive regulation of transcription by RNA polymerase II; cell differentiation involved in embryonic placenta development; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	9247
	107889
	ENSG00000124827
	ENSMUSG00000021362
	O75603
	O09102
	NM_004752
	NM_008104
	NP_004743
	NP_032130
	Wikidata
View/Edit Human	View/Edit Mouse

Chorion-specific transcription factor GCMb is a protein that in humans is encoded by the GCM2 gene.

The Drosophila 'glial cells missing' (gcm) gene is thought to act as a binary switch between neuronal and glial cell determination. The gcm protein and mammalian gcm homologs contain a conserved N-terminal gcm motif that has DNA-binding activity. See GCM1 (MIM 603715).[supplied by OMIM]