GCNT2

GCNT2
Identifiers
Aliases	GCNT2, CCAT, CTRCT13, GCNT2C, GCNT5, IGNT, II, NACGT1, NAGCT1, ULG3, bA360O19.2, bA421M1.1, glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group), glucosaminyl (N-acetyl) transferase 2 (I blood group)
External IDs	OMIM: 600429; MGI: 1100870; HomoloGene: 41535; GeneCards: GCNT2; OMA:GCNT2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	10,629,368 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	41,114,368 bp
RNA expression pattern
	Top expressed in
	gonad; ; left ventricle; ; testicle; ; apex of heart; ; duodenum; ; mucosa of transverse colon; ; prostate; ; stomach; ; human kidney; ; body of stomach;
	Top expressed in
	lumbar spinal ganglion; ; granulocyte; ; right lung lobe; ; olfactory epithelium; ; blood; ; ascending aorta; ; dorsal striatum; ; aortic valve; ; islet of Langerhans; ; tail of embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; glycosyltransferase activity; acetylglucosaminyltransferase activity; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity;
Cellular component	integral component of membrane; Golgi membrane; membrane; cellular component; Golgi apparatus;
Biological process	negative regulation of cell-substrate adhesion; maintenance of lens transparency; positive regulation of heterotypic cell-cell adhesion; positive regulation of cell migration; glycosaminoglycan biosynthetic process; multicellular organism development; protein glycosylation; transforming growth factor beta receptor signaling pathway; positive regulation of cell population proliferation; posttranscriptional regulation of gene expression; positive regulation of epithelial to mesenchymal transition; positive regulation of protein kinase B signaling; positive regulation of ERK1 and ERK2 cascade;
	Sources:Amigo / QuickGO
Orthologs
	2651
	14538
	ENSG00000111846; ENSG00000285222
	ENSMUSG00000021360
	Q8N0V5
	P97402
	NM_001491; NM_145649; NM_145655; NM_001374747
	NM_008105; NM_023887; NM_133219
NP_663624.1; NP_001482.1; NP_663630.2; NP_001482; NP_663624;
	NP_663630; NP_001361676; NP_001482.1; NP_663630.2; NP_663624.1
	NP_032131; NP_076376; NP_573482
	Wikidata
View/Edit Human	View/Edit Mouse

N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase is an enzyme that in humans is encoded by the GCNT2 gene.

This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described.