GCS1

MOGS
Identifiers
Aliases	MOGS, CDG2B, CWH41, DER7, GCS1, mannosyl-oligosaccharide glucosidase
External IDs	OMIM: 601336; MGI: 1929872; HomoloGene: 4593; GeneCards: MOGS; OMA:MOGS - orthologs
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	83,095,879 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; body of stomach; ; stromal cell of endometrium; ; right uterine tube; ; right lobe of thyroid gland; ; minor salivary glands; ; right lobe of liver; ; left lobe of thyroid gland; ; anterior pituitary; ; upper lobe of left lung;
	Top expressed in
	primitive streak; ; Paneth cell; ; condyle; ; cumulus cell; ; somite; ; fossa; ; fetal liver hematopoietic progenitor cell; ; lacrimal gland; ; epiblast; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glucosidase activity; catalytic activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds; Glc3Man9GlcNAc2 oligosaccharide glucosidase activity;
Cellular component	integral component of membrane; extracellular exosome; membrane; endoplasmic reticulum; endoplasmic reticulum membrane;
Biological process	metabolism; protein N-linked glycosylation; protein folding; oligosaccharide metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	7841
	57377
	n/a
	ENSMUSG00000030036
	Q13724
	Q80UM7
	NM_006302; NM_001146158
	NM_020619
	NP_001139630; NP_006293
	NP_065644
	Wikidata
View/Edit Human	View/Edit Mouse

Mannosyl-oligosaccharide glucosidase is an enzyme that in humans is encoded by the MOGS gene.

Glucosidase I is the first enzyme in the N-linked oligosaccharide processing pathway. GCS1 cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. GCS1 is located in the lumen of the endoplasmic reticulum.

GCS1 may also refer to "generative cell specific 1", also called HAP2 (hapless2), a gene of lower eukaryotes which is thought to be responsible for gametes fusion . .