GDF2

GDF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZKZ, 4FAO, 4MPL, 4YCG, 4YCI
Identifiers
Aliases	GDF2, BMP-9, BMP9, HHT5, growth differentiation factor 2
External IDs	OMIM: 605120; MGI: 1321394; HomoloGene: 32299; GeneCards: GDF2; OMA:GDF2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	47,327,588 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	33,669,155 bp
RNA expression pattern
	Top expressed in
	testicle; ; right lobe of liver; ; placenta; ; atrium; ; right atrium; ; right auricle of heart; ; haematopoietic system; ; Hypothalamus; ; ventricle of the heart; ; left ventricle;
	Top expressed in
	hepatobiliary system; ; liver; ; fetal liver hematopoietic progenitor cell; ; embryo; ; left lobe of liver; ; autopod region; ; atrioventricular junction; ; mesenteric lymph nodes; ; abdominal wall; ; calvaria;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; protein binding; transforming growth factor beta receptor binding; growth factor activity;
Cellular component	extracellular exosome; extracellular space; extracellular region;
Biological process	regulation of apoptotic process; pathway-restricted SMAD protein phosphorylation; positive regulation of endothelial cell differentiation; regulation of MAPK cascade; positive regulation of endothelial cell proliferation; blood vessel morphogenesis; negative regulation of blood vessel endothelial cell migration; cell development; SMAD protein signal transduction; ossification; positive regulation of pathway-restricted SMAD protein phosphorylation; cellular response to BMP stimulus; negative regulation of DNA replication; positive regulation of angiogenesis; negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; vasculogenesis; positive regulation of transcription, DNA-templated; cartilage development; positive regulation of gene expression; positive regulation of osteoblast differentiation; positive regulation of cartilage development; negative regulation of cell growth; angiogenesis; osteoblast differentiation; positive regulation of interleukin-8 production; positive regulation of BMP signaling pathway; branching involved in blood vessel morphogenesis; negative regulation of angiogenesis; negative regulation of DNA biosynthetic process; positive regulation of transcription by RNA polymerase II; cellular iron ion homeostasis; activin receptor signaling pathway; BMP signaling pathway; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	2658
	12165
	ENSG00000263761
	ENSMUSG00000072625
	Q9UK05
	Q9WV56
	NM_016204
	NM_019506
	NP_057288
	NP_062379
	Wikidata
View/Edit Human	View/Edit Mouse

Growth differentiation factor 2 (GDF2) also known as bone morphogenetic protein (BMP)-9 is a protein that in humans is encoded by the GDF2 gene. GDF2 belongs to the transforming growth factor beta superfamily.