GDF3

GDF3
Identifiers
Aliases	GDF3, KFS3, MCOP7, MCOPCB6, growth differentiation factor 3
External IDs	OMIM: 606522; MGI: 95686; HomoloGene: 7336; GeneCards: GDF3; OMA:GDF3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	7,695,775 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	122,587,046 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; spleen; ; muscle tissue; ; lymph node; ; smooth muscle tissue; ; right adrenal gland; ; adrenal cortex; ; left adrenal cortex; ; right adrenal cortex;
	Top expressed in
	blastocyst; ; morula; ; embryo; ; gastrula; ; epiblast; ; embryo; ; submandibular gland; ; right ventricle; ; knee joint; ; bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; transforming growth factor beta receptor binding; growth factor activity; protein kinase binding;
Cellular component	extracellular region; extracellular space; cytoplasm;
Biological process	eye development; response to dietary excess; regulation of apoptotic process; skeletal system development; regulation of cell fate commitment; negative regulation of myoblast differentiation; endoderm development; regulation of MAPK cascade; SMAD protein signal transduction; cell development; somite rostral/caudal axis specification; positive regulation of pathway-restricted SMAD protein phosphorylation; notochord development; formation of anatomical boundary; in utero embryonic development; negative regulation of BMP signaling pathway; negative regulation of epidermal cell differentiation; mesoderm development; primitive streak formation; signal transduction; multicellular organism development; positive regulation of fat cell differentiation; regulation of signaling receptor activity; BMP signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9573
	14562
	ENSG00000184344
	ENSMUSG00000030117
	Q9NR23
	Q07104
	NM_020634
	NM_008108
	NP_065685
	NP_032134
	Wikidata
View/Edit Human	View/Edit Mouse

Growth differentiation factor-3 (GDF3), also known as Vg-related gene 2 (Vgr-2) is protein that in humans is encoded by the GDF3 gene. GDF3 belongs to the transforming growth factor beta (TGF-β) superfamily. It has high similarity to other TGF-β superfamily members including Vg1 (found in frogs) and GDF1.