Growth differentiation factor-9

GDF9
Identifiers
Aliases	GDF9, entrez:2661, growth differentiation factor 9, POF14
External IDs	OMIM: 601918; MGI: 95692; HomoloGene: 3851; GeneCards: GDF9; OMA:GDF9 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	132,866,884 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	53,328,731 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; testicle; ; gonad; ; right testis; ; left testis; ; right uterine tube; ; ganglionic eminence; ; tibialis anterior muscle; ; islet of Langerhans;
	Top expressed in
	secondary oocyte; ; primary oocyte; ; zygote; ; egg cell; ; embryo; ; tibiofemoral joint; ; embryo; ; morula; ; morula; ; right ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transforming growth factor beta receptor binding; cytokine activity; growth factor activity;
Cellular component	cytoplasm; extracellular region; extracellular space;
Biological process	regulation of apoptotic process; positive regulation of pathway-restricted SMAD protein phosphorylation; oocyte growth; regulation of MAPK cascade; transforming growth factor beta receptor signaling pathway; SMAD protein signal transduction; female gamete generation; negative regulation of cell growth; BMP signaling pathway; cell development; positive regulation of cell population proliferation; regulation of progesterone secretion; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	2661
	14566
	ENSG00000164404
	ENSMUSG00000018238
	O60383
	Q07105
NM_001288824; NM_001288825; NM_001288826; NM_001288827; NM_001288828;
	NM_005260
	NM_008110
NP_001275753; NP_001275754; NP_001275755; NP_001275756; NP_001275757;
	NP_005251
	NP_032136
	Wikidata
View/Edit Human	View/Edit Mouse

Growth/differentiation factor 9 is a protein that in humans is encoded by the GDF9 gene.

Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function. Growth differentiation factor-9 (GDF9) is expressed in oocytes and is thought to be required for ovarian folliculogenesis. GDF9 is a member of the transforming growth factor-beta (TGFβ) superfamily.