GEN1, Holliday junction 5' flap endonuclease

GEN1
Identifiers
Aliases	GEN1, Gen, Holliday junction 5' flap endonuclease, GEN1 Holliday junction 5' flap endonuclease
External IDs	OMIM: 612449; MGI: 2443149; HomoloGene: 35313; GeneCards: GEN1; OMA:GEN1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	17,788,946 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	11,315,802 bp
RNA expression pattern
	Top expressed in
	testicle; ; bone marrow cells; ; gonad; ; endothelial cell; ; epithelium of nasopharynx; ; ventricular zone; ; pancreatic ductal cell; ; tonsil; ; appendix; ; rectum;
	Top expressed in
	tail of embryo; ; genital tubercle; ; zygote; ; lumbar spinal ganglion; ; yolk sac; ; secondary oocyte; ; maxillary prominence; ; embryo; ; ventricular zone; ; epiblast;
	More reference expression data
	n/a
Gene ontology
Molecular function	crossover junction endodeoxyribonuclease activity; DNA binding; nuclease activity; endonuclease activity; catalytic activity; hydrolase activity; metal ion binding; endodeoxyribonuclease activity; magnesium ion binding; four-way junction DNA binding; 5'-flap endonuclease activity; protein homodimerization activity; double-stranded DNA binding; single-stranded DNA binding; single-stranded DNA 3'-5' exodeoxyribonuclease activity; double-stranded DNA 3'-5' exodeoxyribonuclease activity; single-stranded DNA 5'-3' exodeoxyribonuclease activity; flap endonuclease activity; double-stranded DNA 5'-3' exodeoxyribonuclease activity; 5'-3' exodeoxyribonuclease activity;
Cellular component	centrosome; nucleus; nucleoplasm;
Biological process	resolution of recombination intermediates; positive regulation of mitotic cell cycle spindle assembly checkpoint; regulation of centrosome duplication; resolution of mitotic recombination intermediates; nucleic acid phosphodiester bond hydrolysis; cellular response to DNA damage stimulus; DNA repair; double-strand break repair via homologous recombination; replication fork processing; DNA catabolic process, endonucleolytic; DNA catabolic process, exonucleolytic; UV-damage excision repair;
	Sources:Amigo / QuickGO
Orthologs
	348654
	209334
	ENSG00000178295
	ENSMUSG00000051235
	Q17RS7
	Q8BMI4
	NM_001130009; NM_182625
	NM_177331
	NP_001123481; NP_872431
	NP_796305
	Wikidata
View/Edit Human	View/Edit Mouse

GEN1, Holliday junction 5' flap endonuclease is a protein that in humans is encoded by the GEN1 gene.