GFI1

GFI1
Identifiers
Aliases	GFI1, GFI-1, GFI1A, SCN2, ZNF163, growth factor independent 1 transcriptional repressor
External IDs	OMIM: 600871; MGI: 103170; HomoloGene: 3854; GeneCards: GFI1; OMA:GFI1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	92,486,925 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	107,873,902 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; bone marrow; ; bone marrow cells; ; trabecular bone; ; body of pancreas; ; testicle; ; thymus; ; blood; ; lymph node; ; spleen;
	Top expressed in
	utricle; ; vestibular sensory epithelium; ; thymus; ; saccule; ; granulocyte; ; spermatocyte; ; bone marrow; ; tongue; ; mesenteric lymph nodes; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; metal ion binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity;
Cellular component	nuclear body; nuclear matrix; transcription repressor complex; nucleus; nucleoplasm;
Biological process	positive regulation of interleukin-6-mediated signaling pathway; negative regulation of neuron projection development; regulation of transcription, DNA-templated; regulation of toll-like receptor signaling pathway; regulation of histone H3-K4 methylation; negative regulation of transcription by RNA polymerase II; regulation of transcription involved in G1/S transition of mitotic cell cycle; transcription, DNA-templated; negative regulation of vitamin D biosynthetic process; negative regulation of calcidiol 1-monooxygenase activity; viral process; negative regulation of transcription, DNA-templated; negative regulation of NF-kappaB transcription factor activity; cellular response to lipopolysaccharide; hemopoiesis; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	2672
	14581
	ENSG00000162676
	ENSMUSG00000029275
	Q99684
	P70338
	NM_001127215; NM_001127216; NM_005263
	NM_001267621; NM_010278
	NP_001120687; NP_001120688; NP_005254
	NP_001254550; NP_034408
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein Gfi-1 is a transcriptional repressor that in humans is encoded by the GFI1 gene. It is important normal hematopoiesis. Gfi1 (growth factor independence 1) is a transcriptional repressor that plays a critical role in hematopoiesis and in protecting hematopoietic cells against stress-induced apoptosis. Recent research has shown that Gfi1 upregulates the expression of the nuclear protein Hemgn, which contributes to its anti-apoptotic activity. This upregulation is mediated through a specific 16-bp promoter region and is dependent on Gfi1’s interaction with the histone demethylase LSD1.

Gfi1 represses PU.1, and this repression precedes and correlates with the upregulation of Hemgn. The upregulation of Hemgn, in turn, contributes to the anti-apoptotic function of Gfi1, acting in a p53-independent manner.

These findings suggest that Gfi1 promotes cell survival by upregulating Hemgn through the repression of PU.1, offering a new understanding of its role in apoptosis regulation.