GFM1

GFM1
Identifiers
Aliases	GFM1, COXPD1, EFG, EFG1, EFGM, EGF1, GFM, hEFG1, G elongation factor, mitochondrial 1, G elongation factor mitochondrial 1, mtEF-G1
External IDs	OMIM: 606639; MGI: 107339; HomoloGene: 6449; GeneCards: GFM1; OMA:GFM1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	158,692,575 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	67,383,862 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; biceps brachii; ; Brodmann area 23; ; Skeletal muscle tissue of biceps brachii; ; retinal pigment epithelium; ; Skeletal muscle tissue of rectus abdominis; ; right ventricle; ; germinal epithelium; ; mucosa of sigmoid colon; ; parietal pleura;
	Top expressed in
	myocardium of ventricle; ; otic placode; ; right kidney; ; cardiac muscles; ; cardiac muscle tissue of left ventricle; ; digastric muscle; ; masseter muscle; ; right ventricle; ; proximal tubule; ; temporal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; GTPase activity; translation elongation factor activity; RNA binding;
Cellular component	mitochondrial matrix; intracellular anatomical structure; mitochondrion;
Biological process	translational elongation; protein biosynthesis; mitochondrial translational elongation;
	Sources:Amigo / QuickGO
Orthologs
	85476
	28030
	ENSG00000168827
	ENSMUSG00000027774
	Q96RP9
	Q8K0D5
	NM_001308164; NM_001308166; NM_024996
	NM_138591
NP_001295093; NP_001295095; NP_079272; NP_001361284; NP_001361285;
	NP_001361286; NP_001361287; NP_001361288; NP_001361289; NP_001361290
	NP_613057
	Wikidata
View/Edit Human	View/Edit Mouse

Elongation factor G 1, mitochondrial is a protein that in humans is encoded by the GFM1 gene. It is an EF-G homolog.

Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known.